Help I'm having fits with the template!

I have been doing this blog thing for a few months now. I enjoy wandering around the blog-o-sphere checking out other people's places. I have seen some very creative things out there. I really want to change my template to this one I found on pyzam.com I love this template but can not for the life of me figure out how to change it. Any ideas or pointers from fellow bloggers out there would be appreciated!